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SKC800 AUTOMATIC STAINLESS STEEL BIOREACTOR

SKC800 pilot and production stainless steel bioreactor provides a new solution for the development of bioprocess with its excellent performance and moderate scale.
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SKC800 75L pilot and production stainless steel bioreactor provides new solutions for the development of bioprocesses

with its excellent performance and moderate scale.

It adopts the biological reaction process control algorithm independently developed by CEKG and has a highly

controllable culture environment. Through stirring, temperature, pH, DO, deep ventilation, surface ventilation, peristaltic

pump, defoaming and liquid level, weighing, The control of cold spot detection and additional analog input and output

provide suitable cell growth conditions to achieve batch culture, fed-batch culture and continuous perfusion culture,

thereby achieving high-density culture and high-yield production.

For fabric carrier adherent culture, especially for secreted products, e.g. CHO for EPO/TPO,

VERO cells for human rabies vaccine/Japanese encephalitis vaccine/COVID-19 vaccines/

MDCK cells for flu vaccines, etc.

For micro-carrier adherent culture, e.g. VERO cells/diploid cells for human rabies vaccine, etc

For suspension cell culture, e.g. CHO cell antibody/SF9 cell cervical cancer vaccine, etc.

Vessel volume

Total volume

40L                                   75L                                   150L                                  300L

Working volume

10.75-32.0L                         18.75-60.0L                         37.5-120.0L                         75.5-240.0L

Control system

Siemens PLC, Siemens touch screen, 3 pumps, Ethernet interface, USB interface

Temperature control

Agitating system

Water jacket, electrical-heater PID automatic control, Pt100 sensor, control accuracy ±0.1℃, PID control, temperature control range 8-45℃ above, Max. 60℃

 

Agitating form

Upper mixing, double seal（Bottom magnetic stirring optional）

Impeller

Pitched blade/basket impeller/cell lift impeller/spin filter impeller optional

Agitating speed

Load

25-200rpm                          25-150rpm                          25-120rpm                          25-100rpm

 

Weighing module

0-40kg

Cascaded by pump 

0-100kg

Cascaded by pump

0-200kg

Cascaded by pump

0-300kg

Cascaded by pump

Sparger※

4 gas mixing, 1 or 4 thermal mass flow controllers optional

Overlay ※

4 gas mixing, 1 or 4 thermal mass flow controllers optional

Exhaust

Exhaust condenser, exhaust filter heater

Gas distributor※

Circinate. Micro and macro sparge optional

pH※

2-12, PID control cascaded by pumps/gas flow. ISM probe optional

DO※

0-200%, PID control, cascaded by agitation/pumps/gas flow. ISM probe/optical probe optional

Sterilization

Automatic SIP

Cold spot detection ※

Optional, cold spot monitoring and FO value calculation during sterilization in place

Pumps※

Fixed-speed pumps for addition/acid/base/anti-foam etc., speed 100PRM

Level and anti-foam※

1 level probe. High level probe optional

SCADA※

Optional. GMP/GAMP standards.

Utilities

Water: 50um filtration; industrial steam 30-35PSIG, pure steam 30-35PSIG; 4 gases 30-35PSIG

 

  

Power supply

AC380V，50/60Hz

High quality solutions for the entire industry chain from materials to equipment

Wuhan CEKG TECH. Co., Ltd. owns its own brand CEKG, focusing on providing cell culture equipment and consumables for vaccine, cell and gene therapy, antibody, in vitro diagnosis and other industries. Through the unremitting efforts of the team, the company has become an advanced high-tech enterprise in the industry. It has applied for 46 patents, won the honorary title of high-tech enterprise, Wuhan City "Optical Valley Gazelle" enterprise and "Hubei Province Specialized, Special and new" enterprise, and passed the ISO9001 quality system certification.